What is Tramadol Ingredients? List Of Tramadol Ingredients
What Do You Mean By Tramadol Ingredients?
An ingredient is a substance that forms part of a mixture (in a general sense). For example, in cooking, recipes specify which ingredients are used to prepare a specific dish. In the , an active ingredient is that part of a formulation that yields the effect expected by the customer.
List of Tramadol Ingredients
In the pharmaceutical industry, an active ingredient is present along with excipients that are part of a formulation that yields specific product for customers.
Tramadol contain 50 mg tramadol hydrochloride per capsule/pill.
- magnesium stearate
- sodium starch glycollate
- silica-colloidal anhydrous
- iron oxide yellow (CI 77492)
- titanium dioxide
- Sodium lauryl sulphate
TRAMADOL capsules and injections do not contain lactose, sucrose, tartrazine or any other azo dyes.
Excipient (pharmacologically inactive substance- do not have any pharmacological effect)
What is it?
Microcrystalline cellulose (C6H10O5)n is refined wood pulp. It is a white, free-flowing powder. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. In large quantities it provides dietary bulk and may lead to a laxative effect.
Microcrystalline cellulose is a commonly used excipient in the pharmaceutical industry. It has excellent compressibility properties and is used in solid dose forms, such as tablets. Tablets can be formed that are hard, but dissolve quickly. Microcrystalline cellulose is the same as cellulose, except that it meets USP standards.
It is also found in many processed food products, and may be used as an anti-caking agent, stabilizer, texture modifier, or suspending agent among other uses. According to the Select Committee on GRAS Substances, microcrystalline cellulose is generally regarded as safe when used in normal quantities.
Magnesium stearate is a fine white power that sticks to your skin and is greasy to the touch. It’s a simple salt made up of two substances, a saturated fat called stearic acid and the mineral magnesium. Magnesium stearate is an additive that’s primarily used in medication capsules. It’s considered a “flow agent.” It prevents the individual ingredients in a capsule from sticking to each other and the machine that creates the capsules. It helps improve the consistency and quality control of medication capsules.
It’s possible to create medication capsules without magnesium stearate, but it’s more difficult to guarantee the consistency and quality of those capsules. Magnesium stearate is used to delay breakdown and absorption of medications, so they’re absorbed in the correct area of the bowel.
Sodium Starch Glycollate
Sodium starch glycolate is the sodium salt of carboxymethyl ether. Starch glycolates are of rice, potato, wheat or corn origin. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder.
Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. It is used as a disintegrant, a suspending agent and as a gelling agent. Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.
Silicon dioxide (SiO2), or silica, is known in nature as sand or quartz. It occurs naturally in the earth’s crust, and silicates are present in water, animals and plants. Silicates are also consumed as part of the natural human diet.
In the pharmaceutical industry, silicon dioxide (also known as colloidal silicon dioxide) has many uses in tablet-making: some include as an anti-caking agent, adsorbent, disintegrant, or glidant to allow powder to flow freely when tablets are processed. These compounds appear to be biologically inert. Silicon dioxide is generally recognized as safe by the FDA.
Iron Oxide Yellow
FDA regulates color additives used in foods, drugs, cosmetics, and medical devices. Ferric oxide yellow is an inorganic yellow pigment used in the pharmaceutical industry as a coating pigment. It is also known as yellow iron oxide [FeOH3]. It exists as an amorphous yellow powder, and is primarily used in the cosmetics industry.
- Titanium Dioxide
In the pharmaceutical industry, titanium dioxide is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups. In the cosmetics industry, it is used in toothpaste, lipsticks, creams, ointments and powders. It can be used as an opacifier to make pigments opaque.
Sodium lauryl sulfate
Sodium lauryl sulfate (C12H25SO4Na) is a surface-active agent used in cleaning and cosmetic products. It is also known by the term sodium dodecyl sulfate. It is used in industrial strength degreasers, floor cleaners, bubble bath and toothpastes. In the pharmaceutical industry, it has been used as an excipient in dissolvable dosage forms.