Tapentadol Drug Test Information, Over Dosage, Side Effects and Interactions

Introduction of Tapentadol

Tapentadol Tablets
Tapentadol Tablets

Tapentadol is a single molecule able to bring analgesia by two distinct mechanisms, a characteristic which differentiates it from numerous other analgesics. Pre-clinical information reveals two mechanisms of action: mu-opioid receptor agonist activity and noradrenaline re-uptake inhibition. One might anticipate that tapentadol would be appropriate across a broad spectrum of pain from nociceptive to neuropathic. The scientific research and subsequent practice experience and observation support the idea of opioid and non-opioid mechanisms of action. The diminished occurrence of some of the typical opioid-induced side effects, contrasts to equianalgesic dosage of classical opioids, supports the hypothesis that tapentadol analgesia is only partly mediated by opioid agonist mechanisms. Both the pre-clinical and clinical profiles show to be made different from those of classical opioids.

What is the Tapentadol Drug Test?

Tapentadol is a synthetic, centrally acting analgesic, with both opioid and non-opioid mechanisms of action: Mu-opioid receptor (MOR) agonist and norepinephrine re-uptake inhibition, also known as noradrenaline (NA) re-uptake inhibition (NRI). Being an active compound and not a pro-drug, it is not dependent on enzyme systems, and it is also devoid of dynamic metabolites.

Tapentadol has been studied in a several acute and chronic pain conditions including post-surgical, musculoskeletal and neuropathic pains. Nearly 3000 patients with predominantly severe osteoarthritis (OA) pain or low back pain, tapentadol generic PR (prolonged release) was compared to placebo and an active comparator, oxycodone CR (controlled release) in a joint analysis of three randomized controlled trials in chronic pain.

Both of the active comparators were considerably superior to placebo, and tapentadol drug test confirmed analgesic effectiveness which was ‘non-inferior’ to oxycodone CR. Currently, an extra planned analysis of this facts set has shown superiority for tapentadol over oxycodone. Furthermore, individuals using tapentadol PR experienced enhanced tolerability with lesser side effects specifically for the period of the titration phase compared to individuals using oxycodone CR.

In disparity, individuals taking oxycodone CR displays higher rates of early medication discontinuation, attributed to gastrointestinal side effects typically connected with opioids constipation, nausea and vomiting. The tapentadol group patients had a similar discontinuation rate (36.8%) to patients taking placebo (35.0%), both of which were noticeably lesser than for patients taking oxycodone (55.4%). This enhanced tolerability profile would seem to be compatible with the pre-clinical study proof that tapentadol’s effectiveness is only partly derived from opioid-mediated mechanisms and therefore has a clinical profile different to a pure MOR agonist. Tapentadol’s non-opioid NRI mechanism of action may add to its established analgesic effectiveness in individuals with painful diabetic neuropathy.

What Kind of Information I Should Know About Tapentadol

Tapentadol has been studied in a several acute and chronic pain conditions including post-surgical, musculoskeletal and neuropathic pains. Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Risk of Medication Errors:

Make certain correctness when prescribing, dispensing, and administering tapentadol. Dosing mistakes due to uncertainty between mg and ml can result in unintentional overdose and death.

Addiction, Abuse, and Misuse:

Tapentadol expose patients and other users to the dangers of opioid addiction, abuse, and misuse, which can lead to overdose and death. Evaluate every patient’s risk before prescribing Tapentadol, and supervise all patients frequently for the advances of these behaviors and conditions.

Life-Threatening Respiratory Depression:

Serious, life-threatening, or severe respiratory depression may happen with use of Tapentadol brand name. Observe for respiratory depression, particularly during beginning of Tapentadol or following a dose increase.

Accidental Ingestion:

Inadvertent intake of even one dose of tapentadol can result in a deadly overdose of tapentadol specifically by children.

What Information I Should Know About Tapentadol
What Information I Should Know About Tapentadol

Neonatal Opioid Withdrawal Syndrome:

Lengthened use of tapentadol throughout pregnancy can effect in neonatal opioid withdrawal syndrome, which may be life-threatening if not familiar and treated, and needed management according to protocols developed by neonatology experts. Advise the patient of the risk of neonatal opioid withdrawal syndrome and make certain that suitable medication will be available if opioid use is necessary for a extended period in a pregnant woman.

Used Dangers from Concomitant:

Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, as well as alcohol, may consequence in profound sedation, respiratory depression, coma, and death.

Benzodiazepines or Other CNS Depressants:

Reserve concomitant prescribing of tapentadol and benzodiazepines or other CNS depressants for use in patients for who substitute treatment option are insufficient. Limit dosages and durations to the minimum needed. Track patients for any indications and symptoms of respiratory depression and sedation.

Why This Tapentadol Medication Prescribed?

Tapentadol is a strong painkiller which belongs to the class of opioids. Tapentadol is used in adults for the medication of moderate to severe pain of current onset that can only be sufficiently managed with an opioid painkiller.

Only as directed by your doctor you are to take this drug. Avoid taking more of it, do not take it more often, and avoid taking it for a longer time than your doctor prescribed. This is especially vital for elderly patients, who may be more susceptible to the effects of pain medicines. It may become habit-forming (causing mental or physical dependence) or cause an overdose if too much of this medicine is taken for a long period of time.

It is very significant that you comprehend the rules of the Opioid Analgesic REMS program to avoid addiction, abuse, and misuse of tapentadol. This medication should also come with a Medication Guide. Study and follow these directions cautiously. Read it again each time you replenish your medicine in case there is new information. Consult your doctor if you have any inquiry.

You can take this drug with or without food. Consume the extended-release tablet whole, one tablet at a time, with adequate water. Do not crush, break, dissolve, or chew it. Measure the oral liquid with the marked dosing syringe that comes with the package. Your dosage requires to be measured and given precisely to avoid an overdose. If you want to know more information about Pain Killer Pills click here.

Before Taking Tapentadol Medicine

Before Taking Tapentadol Medicine
Before Taking Tapentadol Medicine

To be certain that you can all right to take tapentadol, tell your doctor if you have any of these conditions manifest:

  • asthma, COPD, sleep apnea, or other breathing disorders;
  • liver or kidney disease;
  • curvature of the spine;
  • a history of head injury or brain tumor;
  • epilepsy or other seizure disorder;
  • gallbladder disease or pancreas problems;
  • mental illness; or
  • a history of drug or alcohol addiction.

If you are allergic to tapentadol you should not take this medicine, or if you have severe liver or kidney ilness, if you are having an asthma attack, or if you have a bowel obstruction called paralytic ileus.

Avoid taking tapentadol if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could happen, leading to serious side effects.

Inform your doctor if you are pregnant or plan to become pregnant during medication. It is not known whether this medicine is damaging to an unborn baby. Tapentadol may cause breathing problems and addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tapentadol can transmit into breast milk and may hurt a nursing baby. Do not breast-feed while taking this medicine. For those who want to know additional information tramadol, look at this website.

How Should Tapentadol Medicine Be Used?

How should Tapentadol Medicine Used
How should Tapentadol Medicine Used

The dosage of this medication will be different for different patients. Follow your doctor's guidelines or the instructions on the label. The following information includes only the standard doses of this medication. Do not modify it except your doctor informs you to do so if your dosage is different.

The quantity of medicine that you take depends on the potency of the drug. In addition, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine will be based on the medical problem for which you are using the medication.

For Oral Dosage Form (Extended-Release Tablets):

For Severe Pain:
  • Adults—the tablet is given every 12 hours. The total amount of milligrams (mg) per day is the same as the total amount of regular tapentadol that is taken per day. The total amount per day will be divided and given as 2 divided doses during the day. The dosage is usually not more than 500 mg per day.
  • Children—Use and dose must be determined by your doctor.
Patients Who Are Not Taking Narcotic Medicines:
  • Adults—in the beginning of medication, 50 milligrams (mg) two times a day (every 12 hours). Your doctor may modify your dose as needed. The dosage is usually not more than 500 mg per day.
  • Children—Use and dose must be determined by your doctor.
Patients Switching From Other Narcotic Medicines:
  • Adults—the tablet is given every 12 hours. The total amount of milligrams (mg) per day will be determined by your doctor and depends on which narcotic you were using. The total amount per day will be divided and given as 2 divided doses during the day. The dosage is usually not more than 500 mg per day.
  • Children—Use and dose must be determined by your doctor.
For Nerve Pain Caused By Diabetes:
  • Adults—at first, 50 milligrams (mg) two times a day (every 12 hours). Your doctor may change your dose as required. The dosage is usually not more than 500 mg per day.
  • Children—Use and dose must be determined by your doctor.

For Oral Dosage form (Immediate-Release Tablets):

For Moderate to Severe Pain:
  • Adults—at first, 50 to 100 milligrams (mg) every 4 to 6 hours. Your doctor may adjust your dose as required.
  • Children—Use and dose must be determined by your doctor.

Over Dosage of Tapentadol

Over Dosage of Tapentadol Pills
Over Dosage of Tapentadol Pills

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Your doctor will change the dose and instance between doses of Tapentadol according to your pain level and your needs. Generally, the lowest pain-relieving dose should be taken.


The usual dose is 1 tablet every 4 to 6 hours. Daily doses greater than 700 mg tapentadol on the first day of medication and every day dosage greater than 600 mg tapentadol on the following days of medication are not advised. Your doctor may prescribe a different, more suitable dosage or timing of dosing, if this is needed for you. If you sense that the effect of these tablets is too strong or weak, consult to your doctor or pharmacist.

How and when should Tapentadol be taken? Tapentadol is for oral use. The medicine is to be swallowing whole with a glass of water. You may take the tablets either on an empty stomach or with food. Avoid taking the medicine for longer than your doctor has told you.

Elderly Patients

In elderly patients (above 65 years) typically no dose modification is needed. However, your doctor may alter your dose or time between doses if necessary.

Patients with Liver or Kidney Problems (Insufficiency)

You cannot take Tapentadol if you have serious liver or kidney problems. If you have moderate liver problems, your doctor will regulate your dose or time between doses. If you have mild liver problems or mild to moderate kidney problems, a dose change is not required.

Children and Adolescents

Tapentadol is not advised for children and adolescents below the age of 18 years.

What Happens If I Overdose The Tapentadol?

If you take more Tapentadol than you should may be life-threatening. Furthermore, immediate medical advice should be required in the incident of a tapentadol overdose, even if you feel well.

Very High Doses of Tapentadol May Cause The Following:
  • pin-point pupils in the eyes
  • being sick (vomiting)
  • drop in blood pressure
  • fast heart beat
  • altered consciousness, collapse or deep unconsciousness (coma)
  • epileptic fits
  • Dangerously slow or shallow breathing or stopping breathing.

If you fail to remember to take the medicine, your pain is likely to return. Do not take a double dose to make up for a forgotten dose, merely carry on taking the tablets as before.

If you cut short or stop medication too soon, your pain is likely to return. Please inform your doctor first before stopping treatment.

Usually there will be no withdrawal effects when medication is stopped. Nonetheless, on uncommon occasions, patients who have been taking the tablets for some time may feel unwell if they suddenly stop taking them. Get additional information regarding hydrocodone pill from our professional team. Let's engage with us.

What Should I Avoid While Taking Tapentadol?

You should inform your doctor or physician if you are taking Tapentadol or any other opioid for constant pain. Here are things to avoid when taking Tapentadol.

The more frequent side effects that can happen with use of carisoprodol include:
  • Driving should be avoided when beginning treatment, or during periods of dose modification, when you are at a greater risk of feeling drowsy, dizzy, having blurred vision or a slow reaction time . If these symptoms are being experienced, avoid using tools or machinery.
  • Avoid taking alcohol as it can lead to excessive drowsiness.
  • You need to make certain that the Doctor who prescribes Tapentadol is aware of all the medicines you are taking, including food and herbal supplements such as St John’s Wort.
  • Suddenly stop taking Tapentadol or you may experience a range of unpleasant side effects.
  • Do not share Tapentadol with anybody.
  • Store Tapentadol in a safe place where other people cannot access it. We advise storing opioids in a locked cupboard.
  • It is also prudent to keep a track on the usage of Tapentadol in case someone is accessing your medicine. Keeping a record will also assist as a prompt to take your tablets.
  • Please report any side effects or if Tapentadol is not lasting 12 hours.
  • Unused tablets should be returned to a Pharmacy department. This reduces the risk of Tapentadol being obtainable to others since it is a drug of abuse. Please do not flush Tapentadol down the toilet or throw tablets away in dustbins.
  • Do not mix Tapentadol with alcohol or other central nervous system depressants such as sleeping tablets and tranquilizers.

Side Effects of Tapentadol

Seek emergency medical help if you have indication of an allergic reaction: hives; chest pain, fast heartbeats, difficult breathing; swelling of your face, lips, tongue, or throat. Opioid medicine can slow or stop your breathing, and death may happen. A person caring for you should get emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Tapentadol can be dosed at 50 mg, 75 mg, or 100 mg every 4 to 6 hours basing upon pain intensity. Tapentadol may interact with cold or allergy medicines, sedatives, narcotic pain medicines, sleeping pills, muscle relaxers, and medicines for seizures, depression or anxiety. Inform your doctor all medicine and supplements you use. Inform your doctor if you are pregnant or plan to become pregnant during treatment with Tapentadol. It is unknown if Tapentadol is harmful to a fetus. Tapentadol can cause breathing troubles and addiction or withdrawal symptoms in a newborn if the mother takes the medicine during pregnancy. Tapentadol can pass into breast milk and may hurt a nursing baby. Breastfeed while taking Tapentadol is not suggested. Withdrawal symptoms may occur if you suddenly stop taking Tapentadol.

Side Effects of Tapentadol
Side Effects of Tapentadol

Hence, consult your doctor immediately if you have tapentadol side effects:

  • weak or shallow breathing, weak pulse, slow heartbeat;
  • a light-headed feeling, like you might pass out;
  • agitation, feeling hot;
  • seizure (convulsions);
  • severe drowsiness or dizziness, confusion, problems with speech or balance;
  • infertility, missed menstrual periods;
  • impotence, sexual problems, loss of interest in sex; or
  • Low cortisol levels -- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated. Long-term use of opioid medicine may affect fertility or the ability to have children in men or women. It is not identified whether opioid effects on fertility are permanent.

Common Side Effects May Comprise:

  • Constipation, mild nausea, stomach pain;
  • Headache, tired feeling; or
  • Mild drowsiness or dizziness.

This is not an entire list of side effects and others may occur. Consult your doctor for medical advice about side effects. You may also report side effects to FDA at 1-800-FDA-1088.

Precautions While Taking Tapentadol

Talk to your doctor or pharmacist before taking Tapentadol if you:
  • have sluggish or shallow breathing
  • suffer from increased pressure in the brain or are not fully conscious
  • have had a head injury or brain tumors
  • suffer from liver or kidney problems
  • suffer from a pancreatic disease including inflammation of the pancreas (pancreatitis) or disease of the bile duct (biliary tract disease)
  • are taking Tapentadol with medicines referred to as mixed opioid agonist/antagonists such as pentazocine, nalbuphine or partial mu-opioid agonists like buprenorphine
  • have a tendency towards epilepsy or fits or if you are taking other medicines known to amplify the risk of seizures because the risk of a fit may boost.
  • Have a tendency to abuse medicines or if you are dependent on medicines, as Tapentadol may lead to addiction. In this case, you should only take these tablets for short periods of time and under strict medical direction.
  • Do not drink alcohol whilst you are using Tapentadol, because some side effects such as drowsiness may be augmented. You can take Tapentadol with or without food.
  • If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, inquire your doctor or pharmacist for advice prior to taking this medicine.

Who Should Not Take Tapentadol:

  • If you are pregnant, unless your doctor has instructed you to do so
  • If you become pregnant during treatment with Tapentadol. Check with your doctor.
  • during childbirth, as it could lead to dangerously slow or shallow breathing (respiratory depression) in the newborn
  • If you are breast-feeding, as it may pass into the breast milk.
  • Driving and using machines
  • Whilst taking Tapentadol and you feel drowsy, dizzy, have blurred vision or a slow reaction time, then do not drive, use tools or machinery.

Any such effects are more likely to happen when you start taking, when the dose of Tapentadol is altered, or when you drink alcohol or take tranquilizers. Ask your doctor before driving a car or using machinery. Want to know the ideal tramadol with aleve, see here.

What Other Drugs Will Affect Tapentadol?

  • If you are taking a type of medicine that affects serotonin levels such as particular medicines to treat depression, consult your doctor before taking Tapentadol as there have been cases of “serotonin syndrome”. Serotonin syndrome is a rare, but life-threatening condition. The signs include involuntary, rhythmic contractions of muscles, including the muscles that control movement of the eye, agitation, excessive sweating, tremor, exaggeration of reflexes, increased muscle tension and body temperature above 38°C. Your doctor can advise you on this.
  • Tapentadol may not work as well if taken with opioid like medicines such as those containing pentazocine, nalbuphine or buprenorphine. Inform your doctor if you are presently being treated with one of these medicines.
  • Taking Tapentadol with products such as rifampicin, phenobarbital or St John’s wort, that affect the enzymes necessary to get rid of Tapentadol from the body, may affect how well Tapentadol works or may cause side effects. The effects may occur particularly when the other medication is started or stopped.
  • Tapentadol should not be taken together with monoamine oxidase inhibitors (MAOIs - certain medicines for the treatment of depression). Inform your doctor if you are taking or have taken MAO inhibitors during the last 14 days.

Keep your doctor informed about all medicines you are taking.

Drug Interactions of Tapentadol

If you are taking, have recently taken or might take any other medicines inform your doctor or pharmacist. Your doctor will let you know which medicines are safe to take with Tapentadol.

The risk of side effects augment if you are taking medicines which may cause convulsions (fits), such as certain antidepressants or antipsychotics. The danger of having a fit may augment if you take Tapentadol at the same time. Your doctor will issue tapentadol warning appropriate for you.

Concomitant use of Tapentadol and sedative medicines such as benzodiazepines or connected drugs particular sleeping pills or tranquillizers like barbiturates or pain relievers such as opioids, morphine and codeine also as cough medicine, antipsychotics, H1-antihistamines, alcohol amplify the risk of drowsiness, difficulties in breathing (respiratory depression), coma and may be life-threatening. Concomitant use should only be considered when other treatment alternatives are not possible.

However if your doctor does prescribe tapentadol together with sedative medicines the dose and period of concomitant treatment should be limited by your doctor inform your doctor about all sedative medicines you are taking, and follow your doctor’s dose advice strictly. It could be helpful to inform friends or relatives to be attentive of the signs and symptoms stated above. Contact your doctor when experiencing such symptoms.