An Overview on Soma (carisoprodol) Pills | Usage, Side Effects, Dosage


Introduction

Carisoprodol (Brand name: Soma) is a medicine drug marketed since 1959. It is a centrally acting muscle relaxant. The diversion and abuse of carisoprodol have increased in the last decade.

Licit Uses:

Carisoprodol is used as an addition to rest, physical therapy and extra measures for relief of acute, painful musculoskeletal conditions. It is available as single-entity tablets containing 250 mg or 350 mg carisoprodol, and as combination tablets containing 200 mg carisoprodol, 325 mg aspirin and 16 mg codeine phosphate. The standard dosage for adults is 250 mg to 350 mg three times daily and at bedtime. Use in patients under age 12 is not recommended.

Chemistry:

Soma (Carisoprodol) is N-isopropyl-2-methyl-2-propyl-1,3- propanediol dicarbamate and is both structurally and pharmacologically related to meprobamate, a Schedule IV substance. It has a chemical structure that gives increase to two optical isomers and is typically found as an equal combination of both, which is referred to as a racemic mixture.

What is Soma (carisoprodol) ?


carisoprodol_350_mg_tablets
carisoprodol_350_mg_tablets

Carisoprodol is the generic form of the prescription Soma drug, which is used to relax muscles and help alleviate pain from muscle spasms. Soma pill (Carisoprodol) belongs to a group of drugs known as soma muscle relaxers.

It was initially approved by the Food and Drug Administration (FDA) in 2007. Soma pills are manufactured by Meda Pharmaceuticals.

Carisoprodol is intended to be used along with rest, physical therapy and other measure to relax muscles after strains, sprains and muscle injuries. It comes in tablet format and is taken by the mouth three times a day and before bed.

Carisoprodol (Somas) has a quick, 30-minute onset of action, with the aforementioned effects lasting about two to six hours. It is metabolized in the liver via the cytochrome P450 oxidase isozyme CYP2C19, excreted by the kidneys and has about an eight-hour half-life. A substantial proportion of carisoprodol is metabolized to meprobamate, which is a known drug of abuse and dependence. This could account for the abuse potential of carisoprodol (meprobamate levels reach higher peak plasma levels than carisoprodol itself following administration). Meprobamate is believed to play a important role in the effects of carisoprodol and meprobamates long half-life results in bioaccumulation following extended periods of carisoprodol administration.

It is somewhat soluble in water and freely soluble in ethanol, chloroform and acetone. The drug's solubility is practically independent of pH.

Important Information About Soma


The Soma functions is effectively to obstruct with pain sensation signaling that happen between peripheral pain receptors (nerves) and specific areas of the central nervous system (the brain). In addition to the alteration of pain signaling, Soma and its main metabolite (meprobamate) exert mild sedative effects.

Many Soma users find the sedative soma side effects to be pleasant which, in turn, can drive a compulsion for constant use.

When taken as prescribed, it is generally viewed as secure. For that reason, it has not yet made it onto the DEA's restricted substances list. However, it can be addictive. In fact, some states have listed Soma as a scheduled substance.

Soma is metabolized in the body to a second compound called meprobamate, which is a Schedule IV substance. Meprobamate was sold as a prescription sedative (trade name: Miltown) beginning in the mid-20th century. It has a established possible for abuse, but as a standalone sedating agent, has been largely substitute these days by benzodiazepines and other types of more effective anti-anxiety medications.

Soma abuse and addiction occur when


  • Soma medicine is taken without regard to intended usage, e.g., inappropriate doses or via alternate methods, such as intravenous administration.
  • Soma is taken for longer periods than intended.
  • Soma drink with or is mixed with other drugs, such as: Vicodin ("Las Vegas Cocktail"), codeine ("Soma Coma"), and Alcohol.
  • Soma can heighten the dangerous effects of all of these substances, making the risks of concurrent use all the more serious. Unfortunately, this has become a common trend, as Soma is a relatively easy to obtain and a popular prescription drug of abuse.

Before taking this medicine


Before taking this medicine
Before taking this medicine

Avoid using this medicine if you are allergic to Soma pills (carisoprodol) or meprobamate, or if you have:

  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).
  • Tell your doctor if you have ever had:
  • liver disease;
  • kidney disease; or
  • a seizure.

It is not known whether this medicine will hurt an unborn baby. There was no study yet with this group. Inform your doctor if you are pregnant. Carisoprodol can pass into breast milk and may cause drowsiness in a nursing baby. Inform your doctor if you are breast-feeding. Carisoprodol is not approved for use by anyone younger than 16 years old. Older adults may be more sensitive to the effects of this medicine.

Follow all instructions on your prescription label and read all medication guides or instruction sheets. Use the medicine precisely as directed. Carisoprodol may be habit-forming. Abuse can cause addiction, overdose, or death. Selling or giving away this medicine is against the law. Carisoprodol is typically taken 3 times per day and at bedtime. Follow your doctor's dosing instructions very cautiously.

Carisoprodol should be taken only 2 or 3 weeks. Call your doctor if your symptoms do not improve, or if they get worse. Avoid stopping using carisoprodol abruptly after long-term use, or you could have unlikable withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Carisoprodol soma is only part of a complete program of medication that may also include rest, physical therapy, or other pain relief measures. Follow your doctor's directions.

Store at room temperature away from moisture and heat. Keep track of your medicine. Carisoprodol is a drug of abuse and you should be attentive if anyone is using it improperly or without a prescription.

How should I take Soma?


How should I take Soma Pills
How should I take Soma Pills

All probable dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose
  • Forms and strengths

It is available as single-entity tablets containing 250 mg or 350 mg carisoprodol, and as combination tablets containing 200 mg carisoprodol, 325 mg aspirin and 16 mg codeine phosphate. The standard dosage for adults is 250 mg to 350 mg three times daily and at bedtime. Use in patients under age 12 is not recommended.


Generic: Carisoprodol

Form: oral tablet

Strengths: 250 mg, 350 mg

Brand: Soma


Form: oral tablet

Strengths: 250 mg, 350 mg

Dosage for muscle pain

Adult dosage (ages 17 to 64 years)


Typical dosage: 250–350 mg, three times per day and at bedtime. This is a total of four times per day (1,400 mg/day).

Child dosage (ages 0 to 16 years) - This medicine has not been studied in children younger than 17 years. It should not be used in children of this age group.

Senior dosage (ages 65 years and older) - This medication has not been studied in adults older than 65 years. It should not be used in people of this age group.

Soma dosing information


Soma prescription is indicated for the relief of discomfort associated with acute, painful musculoskeletal conditions in adults. Soma must only be used for short periods (up to two or three weeks) because sufficient proof of efficiency for more prolonged use has not been established and because acute, painful musculoskeletal conditions are generally of short duration.

The recommended dose of Soma is 250 mg to 350 mg three times a day and at bedtime.

The recommended maximum duration of Soma tablets use is up to two or three weeks.

250 mg Tablets: round, convex, white tablets, inscribed with SOMA 250

350 mg Tablets: round, convex, white tablets, inscribed with SOMA 350

Soma is contraindicated in patients with a history of acute intermittent porphyria or a hypersensitivity reaction to a carbamate such as meprobamate.

Adult dosage (ages 17 to 64 years)


Typical dosage: 250–350 mg, three times per day and at bedtime. This is a total of four times per day (1,400 mg/day).

Child dosage (ages 0 to 16 years) - This medicine has not been studied in children younger than 17 years. It should not be used in children of this age group.

Senior dosage (ages 65 years and older) - This medication has not been studied in adults older than 65 years. It should not be used in people of this age group.

What happens if I miss a dose?


What happens if I overdose?

Overdosage of Soma commonly produces CNS depression. Death, coma, respiratory depression, severe ongoing pain, hypotension, seizures, delirium, hallucinations, dystonic reactions, nystagmus, blurred vision, mydriasis, euphoria, muscular incoordination, rigidity, and/or headache have been reported with Soma overdosage. Many of the SOMA overdoses have happened in the setting of multiple drug overdoses (including drugs of abuse, illegal drugs, and alcohol). The effects of an overdose of SOMA and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) can be chemical addition even when one of the medicines has been taken in the suggested dosage. Fatal accidental and non-accidental overdoses of Soma have been reported single-handedly or in combination with CNS depressants.

Treatment of Overdosage: Essential life support measures should be instituted as dictated by the clinical presentation of the Soma overdose. Induced emesis is not suggested due to the risk of CNS and respiratory depression, which may boost the risk of aspiration pneumonia. Gastric lavage should be considered soon after ingestion (within one hour). Circulatory support should be administered with volume infusion and vasopressor agents if required. Seizures should be treated with intravenous benzodiazepines and the reoccurrence of seizures may be treated with phenobarbital. In cases of severe CNS depression, airway protective reflexes may be compromised and tracheal intubation should be considered for airway protection and respiratory support.

The following types of treatment have been used effectively with an overdose of meprobamate, a metabolite of SOMA:
  • Activated charcoal (oral or via nasogastric tube), forced diuresis, peritoneal dialysis, and hemodialysis (carisoprodol is also dialyzable).
  • cautious monitoring of urinary output is needed and overhydration should be avoided. Observe for possible relapse due to
  • Incomplete gastric emptying and delayed absorption. For more information on the management of an overdose of SOMA, contact a
  • Poison Control Center.

What should I avoid while taking carisoprodol?


Soma comes with several warnings.

Allergy warning: Soma (Carisoprodol) can cause a severe allergic reaction. Symptoms can include:
  • trouble breathing
  • swelling of your throat or tongue
  • If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Do not take this drug again if you’ve ever had an allergic reaction to it or to a drug called meprobamate. Taking it again could be fatal and can cause death.

Alcohol interaction warning: Soma (Carisoprodol) can make you drowsy. The use of drinks that include alcohol can make your drowsiness worse. Speak to your doctor about whether this drug is safe for you if you drink alcohol.

Warnings for people with certain health conditions

  • For people with porphyria: Do not take carisoprodol. It could make your condition worse.
  • For people with an enzyme (CYP2C19) that works gradually: The CYP2C19 enzyme helps your body process carisoprodol. A genetic mutation causes the enzyme to process the drug more slowly. As a result, you may have higher levels of carisoprodol in your body. This raises your risk of side effects. Your doctor may prescribe you a lower dose of this medicine.
  • For people with liver problems: This medicine is processed in your body by your liver. If your liver does not work well, your body may process this drug little by little. This may cause more side effects. To avoid this, your doctor may prescribe you a lower dosage of this drug.
  • For people with kidney problems: This medicine is cleared from your body by your kidneys. If your kidneys do not work well, your body may clear this drug more gradually. This can amplify the amount of the medicine in your body and cause more side effects. To avoid this, your doctor may prescribe you a lower dosage of this drug.

Side Effects Of Soma(carisoprodol)


Soma medication (Carisoprodol )oral tablet may cause drowsiness. Don’t drive or use dangerous machinery until you know how this drug affects you.

Carisoprodol can also cause other side effects.

More common side effects

The more frequent side effects that can happen with use of carisoprodol include:
  • headache
  • dizziness
  • drowsiness

If these side effects are mild, they may go away within a few days or a couple of weeks. If they are more severe or do not go away, discuss with your doctor or pharmacist.

Serious side effects

Inform your doctor immediately if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you are having a medical emergency. Serious side effects and their symptoms can include the following:

  • heart problems, symptoms can include:
  • fast heartbeat
  • low blood pressure, which may cause fainting
  • flushing of the face (sudden reddening)
  • nervous system problems, symptoms can include:
  • trouble making your muscles move the way you want them to
  • feeling agitated or irritated
  • depression
  • seizures
  • shakiness
  • stomach problems, symptoms can include:
  • nausea
  • vomiting
  • pain in the abdomen (stomach area)
  • blood problems, such as a decrease in white blood cells or other types of blood cells; these problems raise your risk of infection

Interactions that increase your risk of side effects

Side effects from other drugs: Taking Soma (carisoprodol) with particular medicine increases your risk of side effects from this medicine. Examples of these drugs include:

  • Benzodiazepines, such as alprazolam, diazepam, or flurazepam.
  • Increased side effects can include drowsiness.

  • Opioids, such as morphine, oxycodone, hydrocodone, or codeine.
  • Increased side effects can include drowsiness.

  • Tricyclic antidepressants, such as amitriptyline, nortriptyline, doxepin, or imipramine.
  • Increased side effects can include drowsiness.

  • Meprobamate.
  • Amplified side effects can comprise drowsiness. This is because your body turns carisoprodol into meprobamate. This augments the amount of meprobamate in your body, and increases its side effects.

Side effects from carisoprodol: Taking carisoprodol with certain medications raises your risk of side effects from carisoprodol. This is because the amount of carisoprodol in your body may be increased. Examples of these drugs include:

  • Drugs such as omeprazole or fluvoxamine.
  • If you take these drugs with carisoprodol, your doctor may monitor you more closely for side effects.

Warnings


Warnings and precaution
Warnings and precaution

Avoid using this medicine if you are allergic to Soma pills (carisoprodol) or meprobamate, or if you have:

  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).
  • Tell your doctor if you have ever had:
  • liver disease;
  • kidney disease; or
  • a seizure.

It is not known whether this medicine will hurt an unborn baby. There was no study yet with this group. Inform your doctor if you are pregnant. Carisoprodol can pass into breast milk and may cause drowsiness in a nursing baby. Inform your doctor if you are breast-feeding. Carisoprodol is not approved for use by anyone younger than 16 years old. Older adults may be more sensitive to the effects of this medicine.

Follow all instructions on your prescription label and read all medication guides or instruction sheets. Use the medicine precisely as directed. Carisoprodol may be habit-forming. Abuse can cause addiction, overdose, or death. Selling or giving away this medicine is against the law. Carisoprodol is typically taken 3 times per day and at bedtime. Follow your doctor's dosing instructions very cautiously.

Carisoprodol should be taken only 2 or 3 weeks. Call your doctor if your symptoms do not improve, or if they get worse. Avoid stopping using carisoprodol abruptly after long-term use, or you could have unlikable withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Carisoprodol soma is only part of a complete program of medication that may also include rest, physical therapy, or other pain relief measures. Follow your doctor's directions.

Store at room temperature away from moisture and heat. Keep track of your medicine. Carisoprodol is a drug of abuse and you should be attentive if anyone is using it improperly or without a prescription.

Sedation

Soma may have sedative properties (in the low back pain trials, 13% to 17% of patients who received Soma experienced sedation compared to 6% of patients who received placebo) and may weaken the mental and/or physical abilities necessary for the performance of potentially hazardous tasks such as driving a motor vehicle or operating machinery.

Since the sedative effects of Soma and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) may be additive, suitable caution should be exercised with patients who take more than one of these CNS depressants concurrently.

Drug Dependence, Withdrawal, and Abuse

In the post marketing experience with Soma, cases of dependence, withdrawal, and abuse have been accounted with extended use. Most cases of dependence, withdrawal, and abuse happened in patients who have had a history of addiction or who used Soma in mixture with other drugs with abuse potential. Withdrawal symptoms have been accounted following sudden termination after prolonged use. To decrease the chance of Soma dependence, withdrawal, or abuse, Soma should be used with caution in addiction prone patients and in patients taking other CNS depressants including alcohol, and Soma should be not be used more than two to three weeks for the relief of acute musculoskeletal discomfort.

One of the metabolites of SOMA, meprobamate (a controlled substance), can cause dependence.

Seizures

There have been postmarketing reports of seizures in patients who received SOMA. Most of these cases have happened in the setting of multiple drug overdoses (including drugs of abuse, illegal drugs, and alcohol).

Do not take this drug again if you’ve ever had an allergic reaction to it or to a drug called meprobamate. Taking it again could be fatal and can cause death.

Alcohol interaction warning: Soma (Carisoprodol) can make you drowsy. The use of drinks that include alcohol can make your drowsiness worse. Speak to your doctor about whether this drug is safe for you if you drink alcohol.

Drug interactions


It is always vital to inform your doctor and pharmacist concerning all of your treatments, including over-the-counter (OTC) medications; vitamins, nutritional shakes, protein powders, and other supplements; herbal treatments or other alternative medicines; and any illegal or recreational drugs.

The following drugs should not be taken while using carisoprodol:
  • Sodium oxybate (Xyrem)
  • Carbinoxamine
  • Clopidogrel (Plavix)
  • Drugs that contain doxylamine
  • Ticlopidine (Ticlid)
Soma (Carisoprodol) can interact with many different groups of drugs, particularly ones that act through your nervous system, such as:
  • Sleep medications, such as opiates
  • Drugs that improve wakefulness, such as modafinil (Provigil) and armodafinil (Nuvigil)
  • Anxiety medications, especially benzodiazepines
  • Many medicines for depression or other psychological conditions.
  • Pain killers, or analgesics
  • Drugs that treat muscle disorders and seizures
  • Other drugs that act on brain receptors or dull the nervous system, such as apormorphine (Apokyn), guanabenz, guanfacine (Estulic, Tenex, Intuniv), and methyldopa (Aldomet)
  • Drugs that help suppress your immune system may also interact with carisoprodol, such as adalimumab (Humira) or belatacept (Nulojix).
  • Allergy medicines like diphenhydramine (Benadryl) and many others can also interact with carisoprodol.

Individuals who are taking the chemotherapy drug acrivastine should not be taking carisoprodol concurrently if possible.

Other drugs can interact with carisoprodol too, such as thalidomide (Thalidomid) and tocilizumab (Actemra).


Carisoprodol and Alcohol
Carisoprodol and Alcohol

Carisoprodol and Alcohol

Drinking alcohol together with taking carisoprodol could worsen drowsiness, your nervous system, and weaken movement. Restrain your consumption of alcohol while taking this drug.

Carisoprodol and Grapefruit Juice

While carisoprodol and grapefruit juice are both broken down in the liver, they are broken down through different pathways. consequently, it is improbable that a reaction would happen.

Carisoprodol and Other Interactions

Medications like the herbal supplement St. John’s wort and the prescription drug rifampin (Rifadin) may decrease carisoprodol’s capability to work.

What other drugs will affect carisoprodol?

Soma (carisoprodol) taken with other drugs can make you sleepy or slow your breathing can cause dangerous side effects or death. Inquire your doctor before taking a sleeping pill, narcotic pain medication, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Inform your doctor about all your present medicines and any you start or stop using, especially:
  • fluoxetine or fluvoxamine;
  • rifampin;
  • St. John's wort;
  • antifungal medicine --ketoconazole, voriconazole;
  • a sedative --diazepam, alprazolam, lorazepam,Valium, Xanax, and others;
  • seizure medicine --carbamazepine, oxcarbazepine; or
  • stomach acid reducers --esomeprazole, lansoprazole, omeprazole, pantoprazole, Nexium, Prilosec.

This is not a complete list. Other drugs may interact with carisoprodol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all likely interactions are listed in this medicine guide. Do not take this drug again if you have ever had an allergic reaction to it or to a drug called meprobamate. Taking it again could be fatal and can cause death.